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The uptake of soluble and nanoparticulate imaging isotope in model liver tumours after intra-venous and intra-arterial administration

Stephens, Ross W; Knox, Karen J; Philip, Lee A; Debono, Kelly M; Bell, Jessica L; King, David W; Parish, Christopher; Senden, Tim J; Tanudji, Marcel R; Winter, Jillean G; Bickley, Stephanie A; Tapner, Michael J.; Pang, Jian H; Jones, Stephen K

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Delivery of chemotherapeutic drugs to tumours by reformulation as nanoparticles has often been proposed as a means of facilitating increased selective uptake, exploiting the increased permeability of the tumour vasculature. However realisation of this improvement in drug delivery in cancer patients has met with limited success. We have compared tumour uptake of soluble Tc99m-pertechnetate and a colloid of nanoparticles with a Tc99m core, using both intra-venous and intra-arterial routes of...[Show more]

dc.contributor.authorStephens, Ross W
dc.contributor.authorKnox, Karen J
dc.contributor.authorPhilip, Lee A
dc.contributor.authorDebono, Kelly M
dc.contributor.authorBell, Jessica L
dc.contributor.authorKing, David W
dc.contributor.authorParish, Christopher
dc.contributor.authorSenden, Tim J
dc.contributor.authorTanudji, Marcel R
dc.contributor.authorWinter, Jillean G
dc.contributor.authorBickley, Stephanie A
dc.contributor.authorTapner, Michael J.
dc.contributor.authorPang, Jian H
dc.contributor.authorJones, Stephen K
dc.date.accessioned2015-06-11T06:27:53Z
dc.date.available2015-06-11T06:27:53Z
dc.identifier.issn0142-9612
dc.identifier.urihttp://hdl.handle.net/1885/13876
dc.description.abstractDelivery of chemotherapeutic drugs to tumours by reformulation as nanoparticles has often been proposed as a means of facilitating increased selective uptake, exploiting the increased permeability of the tumour vasculature. However realisation of this improvement in drug delivery in cancer patients has met with limited success. We have compared tumour uptake of soluble Tc99m-pertechnetate and a colloid of nanoparticles with a Tc99m core, using both intra-venous and intra-arterial routes of administration in a rabbit liver VX2 tumour model. The radiolabelled nanoparticles were tested both in untreated and cationised form. The results from this tumour model in an internal organ show a marked advantage in intra-arterial administration over the intra-venous route, even for the soluble isotope. Tumour accumulation of nanoparticles from arterial administration was augmented by cationisation of the nanoparticle surface with histone proteins, which consistently facilitated selective accumulation within microvessels at the periphery of tumours.
dc.description.sponsorshipSources of support for this research: Sirtex Medical Ltd, Sydney Australia.
dc.publisherElsevier
dc.rights© 2014 Elsevier Ltd. http://www.sherpa.ac.uk/romeo/issn/0142-9612/..."Authors pre-print on any website, including arXiv and RePEC" from SHERPA/RoMEO site (as at 11/06/15)
dc.sourceBiomaterials
dc.subjectarterial administration
dc.subjectimaging isotope
dc.subjectliver cancer
dc.subjectnanoparticle delivery
dc.subjectvascular permeability
dc.titleThe uptake of soluble and nanoparticulate imaging isotope in model liver tumours after intra-venous and intra-arterial administration
dc.typeJournal article
local.identifier.citationvolume39
dcterms.dateAccepted2014-11-03
dc.date.issued2015-01
local.identifier.absfor020406 - Surfaces and Structural Properties of Condensed Matter
local.identifier.absfor111200 - ONCOLOGY AND CARCINOGENESIS
local.identifier.absfor111299 - Oncology and Carcinogenesis not elsewhere classified
local.identifier.ariespublicationU3488905xPUB5121
local.publisher.urlhttp://www.elsevier.com/
local.type.statusSubmitted Version
local.contributor.affiliationStephens, R. W., Research School of Physics and Engineering, The Australian National University
local.contributor.affiliationKnox, K. J., Research School of Physics and Engineering, The Australian National University
local.contributor.affiliationPhilip, L. A., Research School of Biology, The Australian National University
local.contributor.affiliationDebono, K. M., Research School of Biology, The Australian National University
local.contributor.affiliationBell, J. L., Research School of Physics and Engineering, The Australian National University
local.contributor.affiliationKing, D. W., Research School of Physics and Engineering, The Australian National University
local.contributor.affiliationParish, C. R., John Curtin School of Medical Research, The Australian National University
local.contributor.affiliationSenden, T. J., Research School of Physics and Engineering, The Australian National University
local.identifier.essn1878-5905
local.bibliographicCitation.startpage218
local.bibliographicCitation.lastpage224
local.identifier.doi10.1016/j.biomaterials.2014.11.001
dc.date.updated2015-12-11T09:24:02Z
local.identifier.scopusID2-s2.0-84919472926
CollectionsANU Research Publications

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