The uptake of soluble and nanoparticulate imaging isotope in model liver tumours after intra-venous and intra-arterial administration
Stephens, Ross W; Knox, Karen J; Philip, Lee A; Debono, Kelly M; Bell, Jessica L; King, David W; Parish, Christopher; Senden, Tim J; Tanudji, Marcel R; Winter, Jillean G; Bickley, Stephanie A; Tapner, Michael J.; Pang, Jian H; Jones, Stephen K
Delivery of chemotherapeutic drugs to tumours by reformulation as nanoparticles has often been proposed as a means of facilitating increased selective uptake, exploiting the increased permeability of the tumour vasculature. However realisation of this improvement in drug delivery in cancer patients has met with limited success. We have compared tumour uptake of soluble Tc99m-pertechnetate and a colloid of nanoparticles with a Tc99m core, using both intra-venous and intra-arterial routes of...[Show more]
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