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Standard Codon Substitution Models Overestimate Purifying Selection for Nonstationary Data

Kaehler, Benjamin; Yap, Von Bing; Huttley, Gavin


Estimation of natural selection on protein-coding sequences is a key comparative genomics approach for de novo prediction of lineage-specific adaptations. Selective pressure is measured on a per-gene basis by comparing the rate of nonsynonymous substitutions to the rate of synonymous substitutions. All published codon substitution models have been time-reversible and thus assume that sequence composition does not change over time. We previously demonstrated that if time-reversible DNA...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Genome biology and evolution
DOI: 10.1093/gbe/evw308


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