Skip navigation
Skip navigation

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

Pratama, Alvin; Srivastava, Monika; Williams, Naomi J.; Papa, Ilenia; Lee, Sau K.; Dinh, Xuyen T.; Hutloff, Andreas; Jordan, Margaret A.; Zhao, Jimmy L.; Casellas, Rafael; Athanasopoulos, Vicki; Vinuesa, Carola


Tight control of T follicular helper (Tfh) cells is required for optimal maturation of the germinal centre (GC) response. The molecular mechanisms controlling Tfh-cell differentiation remain incompletely understood. Here we show that microRNA-146a (miR-146a) is highly expressed in Tfh cells and peak miR-146a expression marks the decline of the Tfh response after immunization. Loss of miR-146a causes cell-intrinsic accumulation of Tfh and GC B cells. MiR-146a represses several Tfh-cell-expressed...[Show more]

CollectionsANU Research Publications
Date published: 2015-03-06
Type: Journal article
Source: Nature Communications
DOI: 10.1038/ncomms7436


File Description SizeFormat Image
Pratama et al MicroRNA-146a Regulates ICOS-ICOSL 2015.pdf2.65 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator