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Elucidation of the concise biosynthetic pathway of the communesin indole alkaloids

Lin, Hsiao-Ching; Chiou, Grace; Chooi, Yit-Heng; McMahon, Travis C.; Xu, Wei; Garg, Neil K.; Tang, Yi


The communesins are a prominent class of indole alkaloids isolated from Penicillium species. Owing to their daunting structural framework and potential as pharmaceuticals, communesins have inspired numerous synthetic studies. However, the genetic and biochemical basis of communesin biosynthesis has remained unexplored. Herein, we report the identification and characterization of the communesin (cns) biosynthetic gene cluster from Penicillium expansum. We confirmed that communesin is...[Show more]

CollectionsANU Research Publications
Date published: 2015-01-08
Type: Journal article
Source: Angewandte Chemie International Edition
DOI: 10.1002/anie.201411297


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