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Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

Srivastava, Monika; Duan, Guowen; Kershaw, Nadia J; Athanasopoulos, Vicki; Yeo, Janet H. C; Ose, Toyoyuki; Hu, Desheng; Brown, Simon H. J; Jergic, Slobodan; Patel, Hardip R; Pratama, Alvin; Richards, Sashika; Verma, Anil; Jones, E. Yvonne; Heissmeyer, Vigo; Preiss, Thomas; Dixon, Nicholas; Chong, Mark M. W; Babon, Jeffrey J; Vinuesa, Carola G

Description

Roquin is an RNA-binding protein that prevents autoimmunity and inflammation via repression of bound target mRNAs such as inducible costimulator (Icos). When Roquin is absent or mutated (Roquin(san)), Icos is overexpressed in T cells. Here we show that Roquin enhances Dicer-mediated processing of pre-miR-146a. Roquin also directly binds Argonaute2, a central component of the RNA-induced silencing complex, and miR-146a, a microRNA that targets Icos mRNA. In the absence of functional Roquin,...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-20
Type: Journal article
URI: http://hdl.handle.net/1885/13725
Source: Nature Communications
DOI: 10.1038/ncomms7253

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