The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8+ T cells specific for infectious pathogens
It is well established that immunization with attenuated malaria sporozoites induces CD8⁺ T cells that eliminate parasite-infected hepatocytes. Liver memory CD8⁺ T cells induced by immunization with parasites undergo a unique differentiation program and have enhanced expression of CXCR6. Following immunization with malaria parasites, CXCR6-deficient memory CD8⁺ T cells recovered from the liver display altered cell-surface expression markers as compared to their wild-type counterparts, but they...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Infectious Diseases|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.