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The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8+ T cells specific for infectious pathogens

Tse, S.-W.; Radtke, A. J.; Espinosa, D. A.; Cockburn, I. A.; Zavala, F.


It is well established that immunization with attenuated malaria sporozoites induces CD8⁺ T cells that eliminate parasite-infected hepatocytes. Liver memory CD8⁺ T cells induced by immunization with parasites undergo a unique differentiation program and have enhanced expression of CXCR6. Following immunization with malaria parasites, CXCR6-deficient memory CD8⁺ T cells recovered from the liver display altered cell-surface expression markers as compared to their wild-type counterparts, but they...[Show more]

CollectionsANU Research Publications
Date published: 2014-05-13
Type: Journal article
Source: Journal of Infectious Diseases
DOI: 10.1093/infdis/jiu281


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