Skip navigation
Skip navigation

The cellular redox environment alters antigen presentation

Trujillo, Jonathan A.; Croft, Nathan P.; Dudek, Nadine L.; Channappanavar, Rudragouda; Theodossis, Alex; Webb, Andrew I.; Dunstone, Michelle A.; Illing, Patricia T.; Butler, Noah S.; Fett, Craig; Tscharke, David C.; Rossjohn, Jamie; Perlman, Stanley; Purcell, Anthony W.

Description

Cysteine-containing peptides represent an important class of T cell epitopes, yet their prevalence remains underestimated. We have established and interrogated a database of around 70,000 naturally processed MHC-bound peptides and demonstrate that cysteine-containing peptides are presented on the surface of cells in an MHC allomorph-dependent manner and comprise on average 5-10% of the immunopeptidome. A significant proportion of these peptides are oxidatively modified, most commonly through...[Show more]

CollectionsANU Research Publications
Date published: 2014-10-03
Type: Journal article
URI: http://hdl.handle.net/1885/13621
Source: The Journal of Biological Chemistry
DOI: 10.1074/jbc.M114.573402

Download

File Description SizeFormat Image
Trujillo et al final for ANU.pdfAccepted version1.83 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator