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Understanding influenza vaccine protection in the community: an assessment of the 2013 influenza season in Victoria, Australia

Carville, Kylie S.; Grant, Kristina A.; Sullivan, Sheena G.; Fielding, James E.; Lane, Courtney R.; Franklin, Lucinda; Druce, Julian; Kelly, Heath A.

Description

BACKGROUND The influenza virus undergoes frequent antigenic drift, necessitating annual review of the composition of the influenza vaccine. Vaccination is an important strategy for reducing the impact and burden of influenza, and estimating vaccine effectiveness (VE) each year informs surveillance and preventative measures. We aimed to describe the influenza season and to estimate the effectiveness of the influenza vaccine in Victoria, Australia, in 2013. METHODS Routine laboratory...[Show more]

dc.contributor.authorCarville, Kylie S.
dc.contributor.authorGrant, Kristina A.
dc.contributor.authorSullivan, Sheena G.
dc.contributor.authorFielding, James E.
dc.contributor.authorLane, Courtney R.
dc.contributor.authorFranklin, Lucinda
dc.contributor.authorDruce, Julian
dc.contributor.authorKelly, Heath A.
dc.date.accessioned2015-05-26T03:06:35Z
dc.date.available2015-05-26T03:06:35Z
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/1885/13591
dc.description.abstractBACKGROUND The influenza virus undergoes frequent antigenic drift, necessitating annual review of the composition of the influenza vaccine. Vaccination is an important strategy for reducing the impact and burden of influenza, and estimating vaccine effectiveness (VE) each year informs surveillance and preventative measures. We aimed to describe the influenza season and to estimate the effectiveness of the influenza vaccine in Victoria, Australia, in 2013. METHODS Routine laboratory notifications, general practitioner sentinel surveillance (including a medical deputising service) data, and sentinel hospital admission surveillance data for the influenza season (29 April to 27 October 2013) were collated in Victoria, Australia, to describe influenza-like illness or confirmed influenza during the season. General practitioner sentinel surveillance data were used to estimate VE against medically-attended laboratory confirmed influenza. VE was estimated using the case test negative design as 1-adjusted odds ratio (odds of vaccination in cases compared with controls) × 100%. Cases tested positive for influenza while non-cases (controls) tested negative. Estimates were adjusted for age group, week of onset, time to swabbing and co-morbidities. RESULTS The 2013 influenza season was characterised by relatively low activity with a late peak. Influenza B circulation preceded that of influenza A(H1)pdm09, with very little influenza A(H3) circulation. Adjusted VE for all influenza was 55% (95%CI: -11, 82), for influenza A(H1)pdm09 was 43% (95%CI: -132, 86), and for influenza B was 56% (95%CI: -51, 87) Imputation of missing data raised the influenza VE point estimate to 64% (95%CI: 13, 85). CONCLUSIONS Clinicians can continue to promote a positive approach to influenza vaccination, understanding that inactivated influenza vaccines prevent at least 50% of laboratory-confirmed outcomes in hospitals and the community.
dc.format6 pages
dc.publisherElsevier
dc.rights© 2014 Elsevier Ltd.
dc.sourceVaccine
dc.subjectinfluenza
dc.subjectinfluenza season
dc.subjectinfluenza vaccine
dc.subjectinfluenza-like illness
dc.subjectvaccine effectiveness
dc.titleUnderstanding influenza vaccine protection in the community: an assessment of the 2013 influenza season in Victoria, Australia
dc.typeJournal article
local.identifier.citationvolume33
dcterms.dateAccepted2014-11-12
dc.date.issued2015-01-03
local.publisher.urlhttp://www.elsevier.com/
local.type.statusPublished Version
local.contributor.affiliationLane, Courtney R., National Centre for Epidemiology & Population Health, CMBE Research School of Population Health, The Australian National University
local.contributor.affiliationKelly, Heath A., National Centre for Epidemiology & Population Health, CMBE Research School of Population Health, The Australian National University
local.identifier.essn1873-2518
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage341
local.bibliographicCitation.lastpage345
local.identifier.doi10.1016/j.vaccine.2014.11.019
CollectionsANU Research Publications

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