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Retinal microglia: just bystander or target for therapy?

Karlstetter, Marcus; Scholz, Rebecca; Rutar, Matt; Wong, Wai T.; Provis, Jan M.; Langmann, Thomas

Description

Resident microglial cells can be regarded as the immunological watchdogs of the brain and the retina. They are active sensors of their neuronal microenvironment and rapidly respond to various insults with a morphological and functional transformation into reactive phagocytes. There is strong evidence from animal models and in situ analyses of human tissue that microglial reactivity is a common hallmark of various retinal degenerative and inflammatory diseases. These include rare hereditary...[Show more]

CollectionsANU Research Publications
Date published: 2015-03
Type: Journal article
URI: http://hdl.handle.net/1885/13559
Source: Progress in Retinal and Eye Research
DOI: 10.1016/j.preteyeres.2014.11.004

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