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Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study

Ong, K. T; Villemagne, V. L; Bahar-Fuchs, Alex; Lamb, F; Langdon, N; Catafau, A. M; Stephens, A. W; Seibyl, J.; Dinkelborg, L. M; Reininger, C. B; Putz, B; Rohde, B; Masters, C. L; Rowe, C. C


BACKGROUND: We assessed the clinical utility of β-amyloid (Aβ) imaging with ¹⁸F-florbetaben (FBB) in mild cognitive impairment (MCI) by evaluating its prognostic accuracy for progression to Alzheimer's disease (AD), comparing semiquantitative with visual scan assessment, and exploring the relationships among Aβ, hippocampal volume (HV) and memory over time. METHODS: 45 MCI underwent FBB positron emission tomography, MRI and neuropsychological assessment at baseline and 2 years and clinical...[Show more]

CollectionsANU Research Publications
Date published: 2014-06-26
Type: Journal article
Source: Journal of Neurology, Neurosurgery & Psychiatry
DOI: 10.1136/jnnp-2014-308094


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