Post-transcriptional control of IL-17 is DUBA putting the brake on Th17 cells?
In the last decade the concept of T helper (Th) 1- versus Th2-regulated immune responses has been challenged by a number of new subpopulations, including Th17 cells. These proinflammatory cells regulate protection against a variety of bacteria and fungi but have also been connected to almost all major autoimmune diseases.1 Many of the inflammatory effects of Th17 cells are mediated via proinflammatory cytokines such as their namesake, interleukin-17A (IL-17A). Although IL-17A is involved in...[Show more]
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|Source:||Immunology and Cell Biology|