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T cell expansion is the limiting factor of virus control in mice with attenuated TCR signaling: implications for human immunodeficiency

Hillen, Kristina M.; Gather, Ruth; Enders, Anselm; Pircher, Hanspeter; Aichele, Peter; Fisch, Paul; Blumenthal, Britta; Schamel, Wolfgang W.; Straub, Tobias; Goodnow, Christopher C.; Ehl, Stephan


Defining the minimal thresholds for effective antiviral T cell immunity is important for clinical decisions in immunodeficient patients. TCR signaling is critical for T cell development, activation, and effector functions. In this article, we analyzed which of these TCR-mediated processes is limiting for antiviral immunity in a mouse strain with reduced expression of SLP-76 (twp mice). Despite severe T cell activation defects in vitro, twp mice generated a normal proportion of antiviral...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: The Journal of Immunology
DOI: 10.4049/jimmunol.1400328


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