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Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation

Siggs, O. M.; Miosge, L. A.; Daley, Stephen R; Asquith, K.; Foster, P. S.; Liston, A.; Goodnow, C. C.

Description

Gene variants that disrupt TCR signaling can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune pathology. Null mutations of the gene encoding the scaffold protein Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76), for example, cause an arrest of T cell positive selection, whereas a synthetic membrane-targeted allele allows limited positive selection but is associated with proinflammatory cytokine production and autoantibodies....[Show more]

CollectionsANU Research Publications
Date published: 2015-03-15
Type: Journal article
URI: http://hdl.handle.net/1885/13382
Source: The Journal of Immunology
DOI: 10.4049/jimmunol.1400326

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