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Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis

O'Shea, Ross D.; Lau, Chew L.; Zulaziz, Natasha; Maclean, Francesca L.; Nisbet, David R.; Horne, Malcolm K.; Beart, Philip M.


Astrocytes provide trophic, structural and metabolic support to neurons, and are considered genuine targets in regenerative neurobiology, as their phenotype arbitrates brain integrity during injury. Inhibitors of Rho kinase (ROCK) cause stellation of cultured 2D astrocytes, increased L-glutamate transport, augmented G-actin, and elevated expression of BDNF and anti-oxidant genes. Here we further explored the signposts of a cytotrophic, "healthy" phenotype by data-mining of our astrocytic...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-20
Type: Journal article
Source: Frontiers in Neuroscience
DOI: 10.3389/fnins.2015.00050


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