Skip navigation
Skip navigation

Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis

O'Shea, Ross D.; Lau, Chew L.; Zulaziz, Natasha; Maclean, Francesca L.; Nisbet, David R.; Horne, Malcolm K.; Beart, Philip M.

Description

Astrocytes provide trophic, structural and metabolic support to neurons, and are considered genuine targets in regenerative neurobiology, as their phenotype arbitrates brain integrity during injury. Inhibitors of Rho kinase (ROCK) cause stellation of cultured 2D astrocytes, increased L-glutamate transport, augmented G-actin, and elevated expression of BDNF and anti-oxidant genes. Here we further explored the signposts of a cytotrophic, "healthy" phenotype by data-mining of our astrocytic...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-20
Type: Journal article
URI: http://hdl.handle.net/1885/13352
Source: Frontiers in Neuroscience
DOI: 10.3389/fnins.2015.00050

Download

File Description SizeFormat Image
O'Shea et al Transcriptomic Analysis 2015.pdf2.28 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator