Serotonergic Modulation of Glutamate Release in Layer II of Rat Somatosensory Cortex: Mechanisms and Network Specificity
As axons from the raphe nuclei densely innervate the somatosensory cortex, the modulation of transmitter release by serotonin (5-HT) was investigated in pyramidal cells in layer II of rat barrel cortex. The idea was that 5-HT, via presynaptic 5-HT2 receptors (5-HT2R) coupled to Gq proteins, activates Ca2+ release from stores to increase spontaneous transmitter release. Addition of 10 µM 5-HT, in the presence of TTX and gabazine, caused a waxing and waning of...[Show more]
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