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Paternal X inactivation does not correlate with X chromosome evolutionary strata in marsupials

Rodríguez-Delgado, Claudia L.; Waters, Shafagh A.; Waters, Paul D.

Description

BACKGROUND: X chromosome inactivation is the transcriptional silencing of one X chromosome in the somatic cells of female mammals. In eutherian mammals (e.g. humans) one of the two X chromosomes is randomly chosen for silencing, with about 15% (usually in younger evolutionary strata of the X chromosome) of genes escaping this silencing. In contrast, in the distantly related marsupial mammals the paternally derived X is silenced, although not as completely as the eutherian X. A chromosome wide...[Show more]

CollectionsANU Research Publications
Date published: 2014-12-24
Type: Journal article
URI: http://hdl.handle.net/1885/13295
Source: BMC Evolutionary Biology
DOI: 10.1186/s12862-014-0267-z

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