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Expression of TCR-Vβ peptides by murine bone marrow cells does not identify T-cell progenitors

Abbey, Janice; Karsunky, Holger; Serwold, Thomas; Papathanasiou, Peter; Weissman, Irving L; O'Neill, Helen


Germline transcription has been described for both immunoglobulin and T-cell receptor (TCR) genes, raising questions of their functional significance during haematopoiesis. Previously, an immature murine T-cell line was shown to bind antibody to TCR-Vβ8.2 in absence of anti-Cβ antibody binding, and an equivalent cell subset was also identified in the mesenteric lymph node. Here, we investigate whether germline transcription and cell surface Vβ8.2 expression could therefore represent a potential...[Show more]

CollectionsANU Research Publications
Date published: 2015-03-06
Type: Journal article
Source: Journal of Cellular and Molecular Medicine
DOI: 10.1111/jcmm.12572


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