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An investigation into autoimmune pathogenesis by tracking and profiling T cell clones

Singh, Mandeep


Multiple immune tolerance checkpoints ensure that T cells carrying self-reactive T cell receptors (TCRs) are either purged during development or inactivated in the periphery. How these self-reactive T cell clones break tolerance mechanisms and drive disease in autoimmune disorders is poorly understood. When two tolerance checkpoints are crippled in mice by crossing Aire-deficient mice, which have a profound defect in thymic deletion, to Cblb-deficient mice, which display a defect in T cell...[Show more]

CollectionsOpen Access Theses
Date published: 2017
Type: Thesis (PhD)
DOI: 10.25911/5d70f1f9100de


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