An investigation into autoimmune pathogenesis by tracking and profiling T cell clones
Multiple immune tolerance checkpoints ensure that T cells carrying self-reactive T cell receptors (TCRs) are either purged during development or inactivated in the periphery. How these self-reactive T cell clones break tolerance mechanisms and drive disease in autoimmune disorders is poorly understood. When two tolerance checkpoints are crippled in mice by crossing Aire-deficient mice, which have a profound defect in thymic deletion, to...[Show more]
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