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Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice

Morton, Susan K.; Chaston, Daniel J.; Howitt, Lauren; Heisler, Jillian; Nicholson, Bruce J.; Fairweather, Stephen; Broer, Stefan; Ashton, Anthony W.; Matthaei, Klaus I.; Hill, Caryl E.


During activity, coordinated vasodilation of microcirculatory networks with upstream supply vessels increases blood flow to skeletal and cardiac muscles and reduces peripheral resistance. Endothelial dysfunction in humans attenuates activity-dependent vasodilation, resulting in exercise-induced hypertension in otherwise normotensive individuals. Underpinning activity-dependent hyperemia is an ascending vasodilation in which the endothelial gap junction protein, connexin (Cx)40, plays an...[Show more]

CollectionsANU Research Publications
Date published: 2014-12-29
Type: Journal article
Source: Hypertension
DOI: 10.1161/HYPERTENSIONAHA.114.04578


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