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Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

Gan, Lay T.; Van Rooyen, Derrick; Koina, Mark E.; McCuskey, Robert S.; Teoh, Narcissus C.; Farrell, Geoffrey C.

Description

BACKGROUND & AIMS: Free cholesterol (FC) accumulates in non-alcoholic steatohepatitis (NASH) but not in simple steatosis. We sought to establish how FC causes hepatocyte injury. METHODS: In NASH-affected livers from diabetic mice, subcellular FC distribution (filipin fluorescence) was established by subcellular marker co-localization. We loaded murine hepatocytes with FC by incubation with low-density lipoprotein (LDL) and studied the effects of FC on JNK1 activation, mitochondrial injury and...[Show more]

CollectionsANU Research Publications
Date published: 2014-07-24
Type: Journal article
URI: http://hdl.handle.net/1885/13232
Source: Journal of Hepatology
DOI: 10.1016/j.jhep.2014.07.024

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