Combining protein ratio p-values as a pragmatic approach to the analysis of multirun iTRAQ experiments
-
Altmetric Citations
Pascovici, Dana; Song, Xiaomin; Solomon, Peter S.; Winterberg, Britta; Mirzaei, Mehdi; Goodchild, Ann; Stanley, William C.; Liu, Jie; Molloy, Mark P.
Description
iTRAQ labeling of peptides is widely used for quantitative comparison of biological samples using mass spectrometry. However, iTRAQ determined protein ratios have varying credibility depending on the number and quality of the peptide ratios used to generate them, and accounting for this becomes problematic particularly in the multirun scenario needed for larger scale biological studies. One approach to this problem relies on the use of sophisticated statistical global models using peptide...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2014-12-12 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/13078 |
Source: | Journal of Proteome Research |
DOI: | 10.1021/pr501091e |
Download
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator