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Combining protein ratio p-values as a pragmatic approach to the analysis of multirun iTRAQ experiments

Pascovici, Dana; Song, Xiaomin; Solomon, Peter S.; Winterberg, Britta; Mirzaei, Mehdi; Goodchild, Ann; Stanley, William C.; Liu, Jie; Molloy, Mark P.


iTRAQ labeling of peptides is widely used for quantitative comparison of biological samples using mass spectrometry. However, iTRAQ determined protein ratios have varying credibility depending on the number and quality of the peptide ratios used to generate them, and accounting for this becomes problematic particularly in the multirun scenario needed for larger scale biological studies. One approach to this problem relies on the use of sophisticated statistical global models using peptide...[Show more]

CollectionsANU Research Publications
Date published: 2014-12-12
Type: Journal article
Source: Journal of Proteome Research
DOI: 10.1021/pr501091e


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