Skip navigation
Skip navigation

Pathophysiology of T follicular helper cells in humans and mice

Ueno, Hideki; Banchereau, Jacques; Vinuesa, Carola

Description

Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4(+) T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of TFH cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human TFH cells isolated...[Show more]

dc.contributor.authorUeno, Hideki
dc.contributor.authorBanchereau, Jacques
dc.contributor.authorVinuesa, Carola
dc.date.accessioned2015-03-30T00:45:47Z
dc.date.available2015-03-30T00:45:47Z
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/1885/13077
dc.description.abstractFollicular helper T cells (TFH cells) compose a heterogeneous subset of CD4(+) T cells that induce the differentiation of B cells into plasma cells and memory cells. They are found within and in proximity to germinal centers in secondary lymphoid organs, and their memory compartment also circulates in the blood. Our knowledge on the biology of TFH cells has increased significantly during the past decade, largely as a result of mouse studies. However, recent studies on human TFH cells isolated from lymphoid organ and blood samples and recent observations on the developmental mechanism of human TFH cells have revealed both similarities and differences between human and mouse TFH cells. Here we present the similarities and differences between mouse and human lymphoid organ-resident TFH cells and discuss the role of TFH cells in response to vaccines and in disease pathogenesis.
dc.description.sponsorshipSupported by the US National Institutes of Health (U19-AI057234, U19-AI082715 and U19-AI089987), the Alliance for Lupus Research, the Baylor Health Care System (H.U.) and the Australian National Health and Medical Research Council (C.G.V.).
dc.publisherNature Publishing Group
dc.rights© 2015 Nature America, Inc. All rights reserved.
dc.sourceNature Immunology
dc.titlePathophysiology of T follicular helper cells in humans and mice
dc.typeJournal article
local.identifier.citationvolume16
dcterms.dateAccepted2014-11-12
dc.date.issued2015-01-16
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu9505948xPUB134
local.publisher.urlhttp://www.nature.com/
local.type.statusPublished version
local.contributor.affiliationVinuesa, C. G., Department of Pathogens and Immunity, John Curtin School of Medical Research, The Australian National University
local.identifier.essn1529-2916
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage142
local.bibliographicCitation.lastpage152
local.identifier.doi10.1038/ni.3054
local.identifier.absseo920108 - Immune System and Allergy
dc.date.updated2015-12-08T10:19:37Z
local.identifier.scopusID2-s2.0-84922936572
CollectionsANU Research Publications

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator