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Separate and interactive contributions of weak inhibitory control and threat sensitivity to prediction of suicide risk

Venables, Noah C; Sellbom, Martin; Sourander, Andre; Kendler, Kenneth S; Joiner, Thomas E; Drislane, Laura E; Sillanmäki, Lauri; Elonheimo, Henrik; Parkkola, Kai; Multimaki, Petteri; Patrick, Christopher J

Description

Biobehavioral dispositions can serve as valuable referents for biologically oriented research on core processes with relevance to many psychiatric conditions. The present study examined two such dispositional variables-weak response inhibition (or disinhibition; INH-) and threat sensitivity (or fearfulness; THT+)-as predictors of the serious transdiagnostic problem of suicide risk in two samples: male and female outpatients from a U.S. clinic (N=1078), and a population-based male military...[Show more]

dc.contributor.authorVenables, Noah C
dc.contributor.authorSellbom, Martin
dc.contributor.authorSourander, Andre
dc.contributor.authorKendler, Kenneth S
dc.contributor.authorJoiner, Thomas E
dc.contributor.authorDrislane, Laura E
dc.contributor.authorSillanmäki, Lauri
dc.contributor.authorElonheimo, Henrik
dc.contributor.authorParkkola, Kai
dc.contributor.authorMultimaki, Petteri
dc.contributor.authorPatrick, Christopher J
dc.date.accessioned2015-03-25T01:55:22Z
dc.date.available2015-03-25T01:55:22Z
dc.identifier.issn0165-1781
dc.identifier.urihttp://hdl.handle.net/1885/13047
dc.description.abstractBiobehavioral dispositions can serve as valuable referents for biologically oriented research on core processes with relevance to many psychiatric conditions. The present study examined two such dispositional variables-weak response inhibition (or disinhibition; INH-) and threat sensitivity (or fearfulness; THT+)-as predictors of the serious transdiagnostic problem of suicide risk in two samples: male and female outpatients from a U.S. clinic (N=1078), and a population-based male military cohort from Finland (N=3855). INH- and THT+ were operationalized through scores on scale measures of disinhibition and fear/fearlessness, known to be related to DSM-defined clinical conditions and brain biomarkers. Suicide risk was assessed by clinician ratings (clinic sample) and questionnaires (both samples). Across samples and alternative suicide indices, INH- and THT+ each contributed uniquely to prediction of suicide risk-beyond internalizing and externalizing problems in the case of the clinic sample where diagnostic data were available. Further, in both samples, INH- and THT+ interactively predicted suicide risk, with individuals scoring concurrently high on both dispositions exhibiting markedly augmented risk. Findings demonstrate that dispositional constructs of INH- and THT+ are predictive of suicide risk, and hold potential as referents for biological research on suicidal behavior.
dc.description.sponsorshipThe research was supported by National Institute of Mental Health Grants MH072850 and MH089727, and U.S. Army Grants W911NF-14-1-0027 and W81XWH-10-2-0181.
dc.format6 pages
dc.publisherElsevier
dc.rights© 2015 Elsevier Ireland Ltd.
dc.sourcePsychiatry research
dc.subjectDisinhibition
dc.subjectFear
dc.subjectSuicide
dc.subjectThreat sensitivity
dc.subjectWeak response inhibition
dc.titleSeparate and interactive contributions of weak inhibitory control and threat sensitivity to prediction of suicide risk
dc.typeJournal article
local.identifier.citationvolume226
dcterms.dateAccepted2015-01-06
dc.date.issued2015-04-30
local.identifier.absfor170106 - Health, Clinical and Counselling Psychology
local.identifier.ariespublicationa383154xPUB1286
local.publisher.urlhttp://www.elsevier.com/
local.type.statusPublished version
local.contributor.affiliationSellbom, Martin, Research School of Psychology, ANU College of Medicine, Biology and Environment, The Australian National University
local.identifier.essn1872-7123
local.bibliographicCitation.issue2-3
local.bibliographicCitation.startpage461
local.bibliographicCitation.lastpage466
local.identifier.doi10.1016/j.psychres.2015.01.018
local.identifier.absseo920209 - Mental Health Services
dc.date.updated2015-12-10T10:29:22Z
local.identifier.scopusID2-s2.0-84925304081
CollectionsANU Research Publications

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