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Genome scale evolution of myxoma virus reveals host-pathogen adaptation and rapid geographic spread

Kerr, Peter J; Rogers, Matthew B; Fitch, Adam; Depasse, Jay V; Cattadori, Isabella M; Twaddle, Alan C; Hudson, Peter J; Tscharke, David C; Read, Andrew F; Holmes, Edward C; Ghedin, Elodie

Description

The evolutionary interplay between myxoma virus (MYXV) and the European rabbit (Oryctolagus cuniculus) following release of the virus in Australia in 1950 as a biological control is a classic example of host-pathogen coevolution. We present a detailed genomic and phylogeographic analysis of 30 strains of MYXV, including the Australian progenitor strain Standard Laboratory Strain (SLS), 24 Australian viruses isolated from 1951 to 1999, and three isolates from the early radiation in Britain from...[Show more]

CollectionsANU Research Publications
Date published: 2013-09-25
Type: Journal article
URI: http://hdl.handle.net/1885/12904
Source: Journal of virology
DOI: 10.1128/JVI.02060-13

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