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An intact signal peptide on dengue virus E protein enhances immunogenicity for CD8+ T cells and antibody when expressed from modified vaccinia Ankara

Quinan, Bárbara R.; Flesch, Inge E. A.; Pinho, Tânia M. G.; Coelho, Fabiana M.; Tscharke, David C.; da Fonseca, Flávio G.

Description

Dengue is a global public health concern and this is aggravated by a lack of vaccines or antiviral therapies. Despite the well-known role of CD8(+) T cells in the immunopathogenesis of Dengue virus (DENV), only recent studies have highlighted the importance of this arm of the immune response in protection against the disease. Thus, the majority of DENV vaccine candidates are designed to achieve protective titers of neutralizing antibodies, with less regard for cellular responses. Here, we used...[Show more]

CollectionsANU Research Publications
Date published: 2014-04-14
Type: Journal article
URI: http://hdl.handle.net/1885/12819
Source: Vaccine
DOI: 10.1016/j.vaccine.2014.03.093

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