Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB/c mice
Vaccinia virus (VACV) strain MVA is a highly attenuated vector for vaccines that is being explored in clinical trials. We compared the CD8(+) T-cell immunogenicity of MVA with that of a virulent laboratory strain of VACV (strain WR) in BALB/c mice by examining epitope-specific responses as well as estimating the total number of activated CD8(+) T cells, irrespective of specificity. We found that MVA elicited total CD8(+) T-cell responses that were reduced by at least 20-fold compared with...[Show more]
|Collections||ANU Research Publications|
|Source:||Immunology and Cell Biology|
|Russell, T. A & Tscharke, D. C. Striking poor CD8+ cell immunogenicity 2014.pdf||530.43 kB||Adobe PDF|
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