Skip navigation
Skip navigation

Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB/c mice

Russell, Tiffany A; Tscharke, David Carl


Vaccinia virus (VACV) strain MVA is a highly attenuated vector for vaccines that is being explored in clinical trials. We compared the CD8(+) T-cell immunogenicity of MVA with that of a virulent laboratory strain of VACV (strain WR) in BALB/c mice by examining epitope-specific responses as well as estimating the total number of activated CD8(+) T cells, irrespective of specificity. We found that MVA elicited total CD8(+) T-cell responses that were reduced by at least 20-fold compared with...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/icb.2014.10


File Description SizeFormat Image
Russell, T. A & Tscharke, D. C. Striking poor CD8+ cell immunogenicity 2014.pdf530.43 kBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator