Ma, Joel Z.; Russell, Tiffany A.; Spelman, Tim; Carbone, Francis R.; Tscharke, David C.
Herpes simplex viruses (HSV) are significant human pathogens that provide one of the best-described examples of viral
latency and reactivation. HSV latency occurs in sensory neurons, being characterized by the absence of virus replication and
only fragmentary evidence of protein production. In mouse models, HSV latency is especially stable but the detection of
some lytic gene transcription and the ongoing presence of activated immune cells in latent ganglia have been used to
suggest that...[Show more]
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