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Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-Cell effector activity during skin infection with HSV-1

Macleod, Bethany L; Bedoui, Sammy; Hor, Jyh Liang; Mueller, Scott N; Russell, Tiffany A; Hollett, Natasha A; Heath, William R; Tscharke, David C; Brooks, Andrew G; Gebhardt, Thomas


Efficient infection control requires potent T-cell responses at sites of pathogen replication. However, the regulation of T-cell effector function in situ remains poorly understood. Here, we show key differences in the regulation of effector activity between CD4+ and CD8+ T-cells during skin infection with HSV-1. IFN-γ-producing CD4+ T cells disseminated widely throughout the skin and draining lymph nodes (LN), clearly exceeding the epithelial distribution of infectious virus. By contrast,...[Show more]

CollectionsANU Research Publications
Date published: 2014-08-14
Type: Journal article
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1004303


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