Chemoenzymatic Routes to Biologically Active Natural Products and Related Compounds
Various genetically modified microorganisms that over-express dioxygenase-type enzymes can be used for the large scale production of compounds such as A (and known as cis-1,2-dihydrocatechols) from the corresponding aromatic precursor. These metabolites, which are almost invariably obtained in near enantiomerically pure form, have served, over many decades, as valuable starting materials in chemical synthesis. The papers presented in this thesis by...[Show more]
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