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Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes

Enders, Anselm; Short, Alanna; Miosge, Lisa A.; Bergmann, Hannes; Sontani, Yovina; Bertram, Edward M.; Whittle, Belinda; Balakishnan, Bhavani; Yoshida, Kaoru; Sjollema, Geoff; Field, Matthew A.; Andrews, T. Daniel; Hagiwara, Hiromi; Goodnow, Christopher C.

Description

IgD and IgM are produced by alternative splicing of long primary RNA transcripts from the Ig heavy chain (Igh) locus and serve as the receptors for antigen on naïve mature B lymphocytes. IgM is made selectively in immature B cells, whereas IgD is coexpressed with IgM when the cells mature into follicular or marginal zone B cells, but the transacting factors responsible for this regulated change in splicing have remained elusive. Here, we use a genetic screen in mice to identify ZFP318, a...[Show more]

CollectionsANU Research Publications
Date published: 2014-03-25
Type: Journal article
URI: http://hdl.handle.net/1885/12618
Source: PNAS 111.12 (2014): 4513-4518
DOI: 10.1073/pnas.1402739111

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