Yabas, Mehmet; Coupland, Lucy A; Cromer, Deborah; Winterberg, Markus; Teoh, Narci C; D'Rozario, James; Kirk, Kiaran; Bröer, Stefan; Parish, Christopher R.; Enders, Anselm
Transmembrane lipid transporters are believed to establish and maintain phospholipid asymmetry in biological membranes; however, little is known about the in vivo function of the specific transporters involved. Here, we report that developing erythrocytes from mice lacking the putative phosphatidylserine flippase
ATP11Cshowed a lower rate ofPStranslocation in vitro compared with erythrocytes from wild-type littermates. Furthermore, the
mutant mice had an elevated percentage of...[Show more]
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