Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span
Transmembrane lipid transporters are believed to establish and maintain phospholipid asymmetry in biological membranes; however, little is known about the in vivo function of the specific transporters involved. Here, we report that developing erythrocytes from mice lacking the putative phosphatidylserine flippase ATP11Cshowed a lower rate ofPStranslocation in vitro compared with erythrocytes from wild-type littermates. Furthermore, the mutant mice had an elevated percentage of...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Biological Chemistry 289.28 (2014): 19531-19537|
|Yabas et al Mice deficient in the putative 2014.pdf||20.22 MB||Adobe PDF|
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