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Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span

Yabas, Mehmet; Coupland, Lucy A; Cromer, Deborah; Winterberg, Markus; Teoh, Narci C; D'Rozario, James; Kirk, Kiaran; Bröer, Stefan; Parish, Christopher; Enders, Anselm

Description

Transmembrane lipid transporters are believed to establish and maintain phospholipid asymmetry in biological membranes; however, little is known about the in vivo function of the specific transporters involved. Here, we report that developing erythrocytes from mice lacking the putative phosphatidylserine flippase ATP11Cshowed a lower rate ofPStranslocation in vitro compared with erythrocytes from wild-type littermates. Furthermore, the mutant mice had an elevated percentage of...[Show more]

CollectionsANU Research Publications
Date published: 2014-06-04
Type: Journal article
URI: http://hdl.handle.net/1885/12545
Source: Journal of Biological Chemistry 289.28 (2014): 19531-19537
DOI: 10.1074/jbc.C114.570267

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