Regulation of miRNA homeostasis by Roquin
Post transcriptional and posttranslational gene regulation by transacting RNA-binding proteins is a rapid and efficient way to modify gene expression and cellular responses. Mutations in these trans-acting factors are often associated with pathology. The protein Roquin, known to bind target mRNAs and promote their decay, has been found to be crucial in the maintenance of peripheral tolerance and the prevention of autoimmunity. Mice homozygous for a point mutation in Roquin (Sanroque) behave...[Show more]
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