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Paramagnetism & structural biology : biochemical & biophysical analysis of imp-1 metallo-beta-lactamase

Carruthers, Thomas James


Resistance to beta-lactam antibiotics by pathogenic bacteria is a global concern. Typically arising between 2 and 3 years after the introduction of the antibiotic into clinical use, it is usually due to beta-lactamase activity. The gene for IMP-1, a metallo-beta-lactamase with two catalytic metal ions, is located on an extremely mobile integron element, enabling the rapid horizontal transfer of beta-lactam resistance between bacterial species, including genera of pathogenically relevant...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)


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