Carruthers, Thomas James
Resistance to beta-lactam antibiotics by pathogenic bacteria is a global concern. Typically arising between 2 and 3 years after the introduction of the antibiotic into clinical use, it is usually due to beta-lactamase activity. The gene for IMP-1, a metallo-beta-lactamase with two catalytic metal ions, is located on an extremely mobile integron element, enabling the rapid horizontal transfer of beta-lactam resistance between bacterial species, including genera of pathogenically relevant...[Show more]
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