Spleen as a site for hematopoiesis
Hematopoiesis occurs throughout the lifespan of an organism and involves the formation of blood cells from hematopoietic stem cell (HSC) which are self-renewing multipotent progenitors. The hematopoietic niche environment comprises nonhematopoietic cells, extracellular matrix components and soluble regulatory factors which contribute to the quiescence, dormancy, self-renewal and differentiation of HSC. While multiple HSC niches have been described in bone...[Show more]
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