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Spleen as a site for hematopoiesis

Lim, Hong Kiat (Don)

Description

Hematopoiesis occurs throughout the lifespan of an organism and involves the formation of blood cells from hematopoietic stem cell (HSC) which are self-renewing multipotent progenitors. The hematopoietic niche environment comprises nonhematopoietic cells, extracellular matrix components and soluble regulatory factors which contribute to the quiescence, dormancy, self-renewal and differentiation of HSC. While multiple HSC niches have been described in bone...[Show more]

CollectionsOpen Access Theses
Date published: 2017
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/122901

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