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Renin–Angiotensin system genetic polymorphisms and brain white matter lesions in older Australians

Assareh, Amelia A.; Mather, Karen A.; Crawford, John D.; Wen, Wei; Anstey, Kaarin; Easteal, Simon; Tan, Xiaoyun; Mack, Holly A.; Kwok, John B.J.; Schofield, Peter R.; Sachdev, Perminder S.


background White matter lesions (WMLs), seen as hyperintensities on T2-weighted magnetic resonance imaging brain scans, are common in the brains of healthy older individuals. They are thought to be related to cerebral small vessel disease and to have a genetic component to their aetiology, and hypertension is thought to be an important risk factor. Genetic polymorphisms in hypertension-related genes may therefore be associated with the formation of WMLs. methods In this study, a sample...[Show more]

CollectionsANU Research Publications
Date published: 2014-08
Type: Journal article
Source: American Journal of Hypertension, 27.9 (2014): 1191-1198
DOI: 10.1093/ajh/hpu035


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