A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux

Abstract

BACKGROUND: Protein synthesis control is important for β-cell fate during ER stress. RESULTS: Increased protein synthesis during chronic ER stress in β-cells involves the transcriptional induction of an amino acid transporter network. CONCLUSION: Increased amino acid uptake in β-cells during ER stress promotes apoptosis. SIGNIFICANCE: Induced expression of a network of amino acid transporters in islets can contribute to chronic ER stress-induced diabetes.