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A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux

Krokowski, Dawid; Han, Jaeseok; Saikia, Mridusmita; Majumder, Mithu; Yuan, Celvie L; Guan, Bo-Jhih; Bevilacqua, Elena; Bussolati, Ovidio; Bröer, Stefan; Arvan, Peter; Tchórzewski, Marek; Snider, Martin D; Puchowicz, Michelle; Croniger, Colleen M; Kimball, Scot R; Pan, Tao; Koromilas, Antonis E; Kaufman, Randal J; Hatzoglou, Maria


BACKGROUND: Protein synthesis control is important for β-cell fate during ER stress. RESULTS: Increased protein synthesis during chronic ER stress in β-cells involves the transcriptional induction of an amino acid transporter network. CONCLUSION: Increased amino acid uptake in β-cells during ER stress promotes apoptosis. SIGNIFICANCE: Induced expression of a network of amino acid transporters in islets can contribute to chronic ER stress-induced diabetes.

CollectionsANU Research Publications
Date published: 2013-06-14
Type: Journal article
Source: Journal of Biological Chemistry 288. 24 (2013): 17202-17213
DOI: 10.1074/jbc.M113.466920


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