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Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve

Bogatikov, Evgenii; Munoz, Carlos; Pakladok, Tatsiana; Alesutan, Ioana; Shojaiefard, Manzar; Seebohm, Guiscard; Föller, Michael; Palmada, Monica; Böhmer, Christoph; Bröer, Stefan; Lang, Florian


Background: The amino acid transporter B0AT1 (SLC6A19) accomplishes concentrative cellular uptake of neutral amino acids. SLC6A19 is stimulated by serum- & glucocorticoid-inducible kinase (SGK) isoforms. SGKs are related to PKB/Akt isoforms, which also stimulate several amino acid transporters. PKB/Akt modulates glucose transport in part by phosphorylating and thus activating phosphatidylinositol-3-phosphate-5-kinase (PIKfyve), which fosters carrier protein insertion into the cell membrane. The...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Cellular Physiology and Biochemistry 30.6 (2012): 1538-1546
DOI: 10.1159/000343341


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