Impaired nutrient signaling and body weight control in a Na⁺ neutral amino acid cotransporter (Slc6a19)-deficient mouse
Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid transporters. To understand the role of epithelial neutral amino acid uptake in whole body homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0) amino acid transporter BᴼAT1 (Slc6a19). A general neutral aminoaciduria was observed similar to human Hartnup disorder which is caused by mutations in SLC6A19. Na⁺ -dependent uptake of neutral amino acids into the intestine and renal...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of biological chemistry 286. 30 (2011): 26638-26651|
|Broer, A. et. al. Impaired nutrient signaling and body weight 2011.pdf||2.26 MB||Adobe PDF|
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