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F420: Characterisation and Catalysis in Mycobacterial Enzymes

Mohamed, Ahmed Elaaf

Description

Experimental UV-visible spectroscopy, computational quantum chemistry and molecular dynamics (MD) simulations have been used to characterise the deazaflavin cofactor F420 and its role in the catalytic activity of a newly classified superfamily of flavin/deazaflavin dependent oxidoreductases (FDORs). Two FDORs were selected to represent the enzyme family as case studies in the detailed investigations; Deazaflavin dependent nitroreductase (Ddn) and Rv2074, which...[Show more]

CollectionsOpen Access Theses
Date published: 2016
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/118237

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