F420: Characterisation and Catalysis in Mycobacterial Enzymes
Experimental UV-visible spectroscopy, computational quantum chemistry and molecular dynamics (MD) simulations have been used to characterise the deazaflavin cofactor F420 and its role in the catalytic activity of a newly classified superfamily of flavin/deazaflavin dependent oxidoreductases (FDORs). Two FDORs were selected to represent the enzyme family as case studies in the detailed investigations; Deazaflavin dependent nitroreductase (Ddn) and Rv2074, which...[Show more]
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