Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression
Background: Despite homeostatic pH regulation, systemic and cellular pH changes take place and strongly influence metabolic processes. Transcription of the glutamine transporter SNAT3 (Slc38a3) for instance is highly up-regulated in the kidney during metabolic acidosis to provide glutamine for ammonia production. Methods: Slc38a3 promoter activity and messenger RNA stability were measured in cultured cells in response to different extracellular pH values. Results: Up-regulation of SNAT3 mRNA...[Show more]
|Collections||ANU Research Publications|
|Source:||Cellular Physiology and Biochemistry 33.5 (2014): 1591-1606|
|Balkrishna et al Expression of glutamine transporter 2014.pdf||1.03 MB||Adobe PDF|
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