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Microparticles mediate hepatic ischemia-reperfusion injury and are the targets of Diannexin (ASP8597)

Teoh, Narci; Ajamieh, Hussam; Wong, Heng Jian; Croft, Kevin; Mori, Trevor; Allison, Anthony; Farrell, Geoffrey Charles

Description

BACKGROUND & AIMS: Ischemia-reperfusion injury (IRI) can cause hepatic failure after liver surgery or transplantation. IRI causes oxidative stress, which injures sinusoidal endothelial cells (SECs), leading to recruitment and activation of Kupffer cells and platelets (by unknown processes) and microcirculatory impairment. We investigated whether injured SECs release microparticles (small fragments shed from outer leaf of the plasma membrane) with inflammatory effects that contribute to...[Show more]

CollectionsANU Research Publications
Date published: 2014-06-23
Type: Journal article
URI: http://hdl.handle.net/1885/11769
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0104376

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