Long-term cognitive correlates of traumatic brain injury across adulthood and interactions with APOE genotype, sex and age cohorts
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Eramudugolla, Ranmalee; Bielak, Allison; Bunce, David; Easteal, Simon; Cherbuin, Nicolas; Anstey, Kaarin
Description
There is continuing debate about long-term effects of brain injury. We examined a range of traumatic brain injury (TBI)variables (TBI history, severity, frequency, and age of injury) as predictors of cognitive outcome over 8 years in an adult population, and interactions with apolipoprotein E (APOE) genotype, sex and age cohorts. Three randomly sampled age cohorts (20–24, 40–44, 60–64 years at baseline; N = 6333) were each evaluated three times over 8 years. TBI variables, based on self-report,...[Show more]
dc.contributor.author | Eramudugolla, Ranmalee | |
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dc.contributor.author | Bielak, Allison | |
dc.contributor.author | Bunce, David | |
dc.contributor.author | Easteal, Simon | |
dc.contributor.author | Cherbuin, Nicolas | |
dc.contributor.author | Anstey, Kaarin | |
dc.date.accessioned | 2014-05-28T01:54:36Z | |
dc.date.created | 2014-04 | |
dc.identifier.issn | 1355-6177 | |
dc.identifier.uri | http://hdl.handle.net/1885/11722 | |
dc.description.abstract | There is continuing debate about long-term effects of brain injury. We examined a range of traumatic brain injury (TBI)variables (TBI history, severity, frequency, and age of injury) as predictors of cognitive outcome over 8 years in an adult population, and interactions with apolipoprotein E (APOE) genotype, sex and age cohorts. Three randomly sampled age cohorts (20–24, 40–44, 60–64 years at baseline; N = 6333) were each evaluated three times over 8 years. TBI variables, based on self-report, were separately modeled as predictors of cognitive performance using linear mixed effects models. TBI predicted longitudinal cognitive decline in all three age groups. APOE ε4 + genotypes in the young and middle-aged groups predicted lower baseline cognitive performance in the context of TBI. Baseline cognitive performance was better for young females than males but this pattern reversed in middle age and old age. The findings suggest TBI history is associated with long-term cognitive impairment and decline across the adult lifespan. A role for APOE genotype was apparent in the younger cohorts but there was no evidence that it is associated with impairment in early old age. The effect of sex and TBI on cognition varied with age cohort, consistent with a proposed neuroprotective role for estrogen. | |
dc.description.sponsorship | The study was supported by the National Health and Medical Research Council (NHMRC) of Australia Unit Grant No. 973302, Program Grant No. 179805, NHMRC project grant No. 157125, grants from the Australian Rotary Health Research Fund, and the Australian Brewers Foundation. Prof Anstey was funded by NHMRC Fellowships No. 1002560, and Dr. Cherbuin by ARC Fellowship 120100227. Dr. Bunce was funded by the Leverhulme Trust, UK. | |
dc.format | 11 pages | |
dc.publisher | Cambridge University Press | |
dc.rights | © INS. Published by Cambridge University Press | |
dc.source | Journal of the International Neuropsychological Society 20. 4 (2014): 444-454 | |
dc.subject | cognitive | |
dc.subject | decline | |
dc.subject | epidemiology | |
dc.subject | head | |
dc.subject | injury | |
dc.subject | dementia | |
dc.subject | prospective | |
dc.subject | study | |
dc.title | Long-term cognitive correlates of traumatic brain injury across adulthood and interactions with APOE genotype, sex and age cohorts | |
dc.type | Journal article | |
local.identifier.citationvolume | 20 | |
dcterms.dateAccepted | 2014-02-11 | |
local.identifier.absfor | 110308 - Geriatrics and Gerontology | |
local.identifier.ariespublication | u4056230xPUB313 | |
local.publisher.url | http://www.cambridge.org/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Eramudugolla, Ranmalee, Centre for Research on Aging, Health and Wellbeing, Australian National University | |
local.contributor.affiliation | Easteal, Simon, John Curtin School of Medical Research, Australian National University | |
local.contributor.affiliation | Cherbuin, Nicolas, Centre for Research on Aging, Health and Wellbeing, Australian National University | |
local.contributor.affiliation | Anstey, Kaarin J., Centre for Research on Aging, Health and Wellbeing, Australian National University | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1002560 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/120100227 | |
local.bibliographicCitation.issue | 4 | |
local.bibliographicCitation.startpage | 444 | |
local.bibliographicCitation.lastpage | 454 | |
local.identifier.doi | 10.1017/S1355617714000174 | |
local.identifier.absseo | 920112 - Neurodegenerative Disorders Related to Ageing | |
dc.date.updated | 2015-12-09T09:56:03Z | |
local.identifier.scopusID | 2-s2.0-84897057556 | |
local.identifier.thomsonID | 000333561900010 | |
dcterms.accessRights | Open Access | |
dc.provenance | http://www.sherpa.ac.uk/romeo/issn/1355-6177/ The author can archive the pre-print (ie pre-refereeing), post-print (ie final draft post-refereeing) and may use the publishers pdf version in institutional repositories after a 12 month embargo period. | |
Collections | ANU Research Publications |
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