Functional Evolution of Solute-Binding Proteins
Solute-binding proteins (SBPs) comprise an abundant and adaptable superfamily of extracytoplasmic solute receptors involved in nutrient uptake and chemotaxis, and constitute an important component of the nutrient-scavenging arsenal in bacteria. The SBP superfamily exemplifies the power of evolution to generate functional diversity by tinkering with an existing protein fold; SBPs have evolved to recognise a wide variety of solutes with high affinity and specificity, and have also been co-opted...[Show more]
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