Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
Lefebure, Marcus; Tothill, Richard W; Kruse, Elizabeth; Hawkins, Edwin D; Shortt, Jake; Matthews, Geoffrey M; Gregory, Gareth P; Martin, Benjamin P; Kelly, Madison J; Todorovski, Izabela; Doyle, Maria A; Lupat, Richard; Li, Jason; Schroeder, Jan; Wall, Meaghan; Craig, Stuart; Poortinga, Gretchen; Cameron, Don; Bywater, Megan; Kats, Lev; Gearhart, Micah D; Bardwell, Vivian J; Dickins, Ross A; Hannan, Ross D; Papenfuss, Anthony T; Johnstone, Ricky W
The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic...[Show more]
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