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GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans

Chitty, Jessica L.; Tatzenko, Tayla L.; Williams, Simon; Koh, Y. Q. Andre E.; Corfield, Elizabeth C.; Butler, Mark S.; Robertson, Avril A. B.; Cooper, Matthew A.; Kappler, Ulrike; Kobe, Bostjan; Fraser, James A.


Over the last four decades the HIV pandemic and advances in medical treatments that also cause immunosuppression have produced an ever-growing cohort of individuals susceptible to opportunistic pathogens. Of these, AIDS patients are particularly vulnerable to infection by the encapsulated yeast Cryptococcus neoformans Most commonly found in the environment in purine-rich bird guano, C. neoformans experiences a drastic change in nutrient availability during host infection, ultimately...[Show more]

CollectionsANU Research Publications
Date published: 2017-02-17
Type: Journal article
Source: The Journal of biological chemistry
DOI: 10.1074/jbc.M116.767533
Access Rights: Open Access


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