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Persistent barrage firing in cortical interneurons can be induced in vivo and may be important for the suppression of epileptiform activity

Suzuki, Norimitsu; Tang, Clara Sze-Man; Bekkers, John MacDonald

Description

Neural circuits are typically maintained in a state of dynamic equilibrium by balanced synaptic excitation and inhibition. However, brain regions that are particularly susceptible to epilepsy may have evolved additional specialized mechanisms for inhibiting over-excitation. Here we identify one such possible mechanism in the cerebral cortex and hippocampus of mice. Recently it was reported that some types of GABAergic interneurons can slowly integrate excitatory inputs until eventually they...[Show more]

CollectionsANU Research Publications
Date published: 2014-03-13
Type: Journal article
URI: http://hdl.handle.net/1885/11626
Source: Frontiers in Cellular Neuroscience 8. 76 (2014): 1-23
DOI: 10.3389/fncel.2014.00076

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