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F-18-florbetaben A beta imaging in mild cognitive impairment

Ong, Kevin; Villemagne, Victor L.; Bahar-Fuchs, Alex; Lamb, Fiona; Chetelat, Gael; Raniga, Parnesh; Mulligan, Rachel S.; Salvado, Olivier; Putz, Barbara; Roth, Katrin; Masters, Colin L.; Reininger, Cornelia B.; Rowe, Christopher C.

Description

F-florbetaben and positron emission tomography were used to examine the relationships between b-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Ab burden. Correlations were adjusted for age, gender and years of education.Results: High A b burden was found in 53%...[Show more]

dc.contributor.authorOng, Kevin
dc.contributor.authorVillemagne, Victor L.
dc.contributor.authorBahar-Fuchs, Alex
dc.contributor.authorLamb, Fiona
dc.contributor.authorChetelat, Gael
dc.contributor.authorRaniga, Parnesh
dc.contributor.authorMulligan, Rachel S.
dc.contributor.authorSalvado, Olivier
dc.contributor.authorPutz, Barbara
dc.contributor.authorRoth, Katrin
dc.contributor.authorMasters, Colin L.
dc.contributor.authorReininger, Cornelia B.
dc.contributor.authorRowe, Christopher C.
dc.date.accessioned2014-05-01T05:17:03Z
dc.date.available2014-05-01T05:17:03Z
dc.identifier.issn1758-9193
dc.identifier.other1758-9193
dc.identifier.urihttp://hdl.handle.net/1885/11600
dc.description.abstractF-florbetaben and positron emission tomography were used to examine the relationships between b-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Ab burden. Correlations were adjusted for age, gender and years of education.Results: High A b burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r= -0.51,P= 0.0015) and hippocampal volume (r= 0.60,P= 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Ab burden.Conclusion: Higher Ab deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
dc.format11 pages
dc.publisherBioMed Central
dc.rightshttp://www.sherpa.ac.uk/romeo/issn/1758-9193/ Author can archive pre-print (ie pre-refereeing); author can archive post-print (ie final draft post-refereeing);author can archive publisher's version/PDF;Creative Commons Attribution Licence;Copy of License must accompany any deposit
dc.sourceAlzheimer’s Research & Therapy 5.1 (2013)
dc.subjectAlzheimers association workgroups
dc.subjectneurofibrillary tangles
dc.subjectamyloid deposition
dc.subjectwhite-matter
dc.subjectin-vivo
dc.subjectdiagnostic guidelines
dc.subjectnational institute
dc.subjectsenile dementia
dc.subjectcompound-b
dc.subjectdisease
dc.titleF-18-florbetaben A beta imaging in mild cognitive impairment
dc.typeJournal article
local.identifier.citationvolume5
dc.date.issued2013
local.identifier.absfor170205 - Neurocognitive Patterns and Neural Networks
local.identifier.ariespublicationu4056230xPUB269
local.publisher.urlhttp://www.biomedcentral.com
local.type.statusPublished Version
local.contributor.affiliationBahar-Fuchs, Alex, Research Centre for Aging Health & Wellbeing
dc.relationhttp://purl.org/au-research/grants/nhmrc/509166
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage11
local.identifier.doi10.1186/alzrt158
local.identifier.absseo920112 - Neurodegenerative Disorders Related to Ageing
dc.date.updated2015-12-09T09:19:50Z
local.identifier.scopusID2-s2.0-84872173056
local.identifier.thomsonID000325285300004
CollectionsANU Research Publications

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