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Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B–NS3 protease

de la Cruz, Laura; Chen, Wan-Na; Graham, Bim; Otting, Gottfried


The two-component dengue virus NS2B–NS3 protease (NS2B–NS3pro) is an established drug target but inhibitor design is hampered by uncertainties about its 3D structure in solution. Crystal structures reported very different conformations for the functionally important C-terminal segment of the NS2B cofactor (NS2Bc), indicating open and closed conformations in the absence and presence of inhibitors, respectively. An earlier NMR study in solution indicated that a closed state is the preferred...[Show more]

CollectionsANU Research Publications
Date published: 2014-03-18
Type: Journal article
Source: the FEBS Journal 281.6 (2014): 1517–1533
DOI: 10.1111/febs.12729
Access Rights: Open Access


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