de la Cruz, Laura; Chen, Wan-Na; Graham, Bim; Otting, Gottfried
The two-component dengue virus NS2B–NS3 protease (NS2B–NS3pro) is an established drug target but inhibitor design is hampered by uncertainties about its 3D structure in solution. Crystal structures reported very different conformations for the functionally important C-terminal segment of the NS2B cofactor (NS2Bc), indicating open and closed conformations in the absence and presence of inhibitors, respectively. An earlier NMR study in solution indicated that a closed state is the preferred...[Show more]
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