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Cyclin E facilitates dysplastic hepatocytes to bypass G(1)/S checkpoint in hepatocarcinogenesis

Pok, Sharon; Wen, Victoria; Shackel, Nicholas; Alsop, Amber; Pyakurel, Pawan; Fahrer, Aude; Farrell, Geoffrey C.; Teoh, Narci C.

Description

Background and Aim: By array-comparative genomic hybridization, we demonstrated cyclin E as one of seven genes associated with hepatocellular carcinoma (HCC) development in Ku70 DNA repair-deficient mice. We therefore explored the hypothesis that during hepatocarcinogenesis, cyclin E kinase can overcome the inhibitory effects of p53 and establish whether abnormal miRNA(mi-R)-34, a co-regulator of cyclin E and p53, can account for their interactions as " drivers" of HCC. Methods: Dysplastic...[Show more]

CollectionsANU Research Publications
Date published: 2013-09
Type: Journal article
URI: http://hdl.handle.net/1885/11496
Source: Journal of Gastroenterology and Hepatology 28.9 (2013): 1545-1554
DOI: 10.1111/jgh.12216

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